Although some
of the protein associated in the detachment,
migration and anchoring within an organ with
tissular specificity different from the
tumor cell origin have been defined; the
mechanism and the molecules associated with
the development of distant metastases have
not. Moreover, epidemiological data suggests
that metastases occur in different organ
based on the tumor origin. Also
understanding the effect of tumor growth
within an organ is also crucial.
In the laboratory this research is conducted
on a breast cancer bone metastases in vivo
model. Additionally, in collaboration with
CMC, the
development of distant liver metastases and
their effects of liver functions are
analyzed.
From a diagnostic standpoint, an
understanding of the minimal features
associated with the development of brain or
liver metastases would be of tremendous help
in the clinical setting.