Research Interests

• Detection and therapeutic intervention in various form of circulatory shock.

Research Projects (last 5 years):

Project title: Diagnostic significance of nontraumatic emergency department hypotension.

Goal: Test the diagnostic ability of SBP < 100 mm Hg to predict in-hospital mortality.

Status: Enrollment ongoing.

 

Project title: Randomized controlled trial of goal-directed ultrasound in the management of non-traumatic undifferentiated hypotension.

Goal: Test if emergency-physician operated ultrasonography can improve the accuracy of the immediate differential diagnosis of non-traumatic hypotension.

Status: Published, Critical Care Medicine, August 2004.

 

Project title: Non-traumatic prehospital hypotension predicts in-hospital mortality.

Goal: Test if exposure to systolic hypotension during ambulance transport is associated with increased risk of death during hospitalization.

Status: Published, Annals Emergency Medicine, 2004.

 

Project title: Focused training of emergency medicine residents in goal-directed echocardiography.

Goal: Test if a focused echocardiography training course would improve the accuracy of completion and interpretation of goal-directed echocardiogram by EM residents.

Status: Published, Academic Emergency Medicine, 2003.

 

Project title: Inhibition of prostaglandin synthesis during polystyrene microsphere-induced pulmonary embolism in the rat.

Goal: Test the effect of inhibition of thromboxane synthase versus cyclooxygenase on pulmonary gas exchange and heart function during simulated PE in the rat.

Professional Experience

• Academic Faculty – Emergency Medicine, Carolinas Medical Center, Charlotte NC                          2003-Present      

• Assistant Director of Research – Emergency Medicine, Carolinas Medical Center, Charlotte NC       2003- Present

• Director, EM Research Associate Program, Carolinas Medical Center and UNCC, Charlotte, NC    2003- Present

Education

• Carolinas Medical Center, Research Fellow, Emergency Medicine, 2002- 2003, Charlotte, NC

• Carolinas Medical Center, Chief Resident, Emergency Medicine, 2001- 2002 Charlotte, NC 

• Carolinas Medical Center, Resident, Emergency Medicine, 1999- 2002 Charlotte, NC 

• University of Mississippi  Doctor of Medicine, 1995- 1999 Jackson, MS - Summa Cum Laude  

• Millsaps College, Bachelor of Science, Molecular Biology, 1990- 1994, Jackson, MS - Magna Cum Laude

• Certification/Licensure: Diplomat American Board of Emergency Medicine                 2003- 2013

Selected Recent Publications

1) JE Herrera, JJ Correia, AE Jones, MOJ Olson.  Sedimentation analysis of salt- and divalent ion- induced oligomerization of nucleolar protein B23.  Biochemistry 35: 2668-2673, 1996.

2) GR Barrett, K Richardson, CG Ruff, AE Jones.  The effect of suture type on meniscus repair: A clinical analysis.  American Journal of Knee Surgery 10: 2-9, 1997.

3) JF Carroll, AE Jones, RL Hester, GA Reinhart, K Cockrell, HL Mizelle.  Reduced cardiac responsiveness to isoproterenol in obese rabbits.  Hypertension 30: 1376-1381, 1997.

4) AE Jones, P Kleinman.  A 49 year old woman with depression, migraine headaches, and partially empty sella syndrome.  Headache 38: 58, 1998.

5) AE Jones, LF Knoepp, DD Oxley.  Broncho-pleural fistula resulting from the use of a thoracic vent:  A case report and review.  Chest 114: 1781-1784, 1998.

6) RL Summers, HL Mizelle, JP Montani, AE Jones.  Validation of a computer model of aortic compliance curves.  Computers in Cardiology 26: 455-458, 1999.

7) AE Jones, RL Summers.  Detection of isopropyl alcohol in a patient with diabetic ketoacidosis.  Journal of Emergency Medicine 19: 165-168, 2000.

8) RL Summers, B McCoy, LH Woodward, AE Jones.  Comparison of noninvasive measures of cardiac function.  ME Journal of Emergency Medicine 1: 31-34, 2001.

9) MA Gibbs, AE Jones.  Cervical spine injury: A state-of-the-art approach to assessment and management.  Emergency Medicine Practice 3: 1-24, October 2001.

10) AE Jones, RL Summers, C Deschamp, RL Galli.  A national survey of the

aeromedical transport of high risk obstetric patients.  Air Medical Journal 6: 17-20, 2001.

11) AE Jones, PE Mason, VS Tayal, MA Gibbs. Sonographic intraperitoneal fluid in patients with pelvic fracture: Two cases of traumatic intraperitoneal bladder rupture.  Journal of Emergency Medicine. 25: 373-377, 2003.

12) AE Jones, JA Watts, J Debelak, LR Thornton, JD Younger, JA Kline.  Inhibition of prostaglandin synthesis during experimental massive pulmonary embolus in the rat. American Journal of Physiology - Lung Cellular and Molecular Physiology 284: L1072-L1081, 2003.

13) AE Jones, VS Tayal, JA Kline. Focused training of emergency medicine residents in goal-directed echocardiography: A prospective study.  Academic Emergency Medicine 10:1054-1058, 2003.

14) AE Jones, JA Kline.  Availability of technology to evaluate for pulmonary embolism in academic emergency departments in the United States. Journal of Thrombosis and Haemostasis 10:2240-2242, 2003.

15) AE Jones, JA Kline.  Elevated brain natriuretic peptide in septic patients without heart failure.  Annals of Emergency Medicine 42:714-715, 2003.

16) AE Jones, IG Stiell, LP Nesbitt, DW Spaite, N Hasan, BA Watts, JA Kline. Nontraumatic out-of-hospital hypotension predicts inhospital mortality. Annals of Emergency Medicine 43:106-113, 2004.

17) AE Jones, VS Tayal, DM Sullivan, JA Kline. Randomized controlled trial of immediate versus delayed goal-directed ultrasound to identify the cause of nontraumatic hypotension in emergency department patients. Critical Care Medicine 32:1703-1708, 2004.

18) JA Kline, WB Webb, AE Jones, J Hernandez. Impact of a rapid rule-out protocol for pulmonary embolism on the rate of screening, missed cases, and pulmonary vascular imaging in an urban US emergency department. Annals of Emergency Medicine 44:490-502, 2004.

19) AE Jones, LS Aborn, JA Kline. Severity of emergency department hypotension predicts adverse hospital outcome. Shock 22:410-414, 2004.

20) AE Jones, MT Fitch, JA Kline. Operational performance of validated physiologic scoring systems for predicting in-hospital mortality among critically ill emergency department patients. Critical Care Medicine, In press 2005.

21) MS Runyon, WB Webb, AE Jones, JA Kline. Unstructured clinician estimate of low clinical probability for pulmonary embolism is equivalent to the Canadian score and the charlotte rule. Academic Emergency Medicine, In press 2005.

Orphaned Abstracts (presented but not published as full-length manuscript):

1) RL Summers, AE Jones, HL Mizelle, LH Woodward.  Reduction in aortic compliance as a marker of coronary disease.  Academic Emergency Medicine 6: 421, 1999.

2) J Patch, RL Summers, AE Jones.  Effect of the initiation of Bi-PAP on hemodynamic stability.  Annals of Emergency Medicine 34: S7, 1999.

3) RL Summers, HL Mizelle, AE Jones, JP Montani.  Effect of primary changes in heart rate on circulatory dynamics. Annals of Emergency Medicine 34: S48, 1999.

4) JC Kolb, RL Summers, AE Jones.  Effect of cold water immersion of finger pulse oximetry readings. Annals of Emergency Medicine 34: S74, 1999.

5) AE Jones,  B Boes, G Haymans, R West, RL Summers, RW Rockhold.  Body weight gain and food intake following recurrent methcathinone intoxication. Annals of Emergency Medicine 34: S30, 1999.

6) AE Jones, HL Mizelle, RL Summers.  Prevalence and determinants of QT dispersion in patients presenting to the emergency department with chest pain. Annals of Emergency Medicine 34: S77, 1999.

7) AE Jones, VS Tayal, MA Gibbs, JA Marx.  Pediatric rapid sequence intubation at an emergency medicine residency: success rate and adverse events.  Annals of Emergency Medicine 38: S9, 2001.

8) AE Jones, M Bush, JW Runge.  Pedestrian injuries: demographics and injury patterns during a one-year period. Annals of Emergency Medicine 38: S55, 2001.

9) DN Cowles, AE Jones, JA Kline.  Operational performance comparison of contrast-enhanced CT scanning with ventilation-perfusion lung scanning for pulmonary embolism. Academic Emergency Medicine 9:462, 2002.

10) A Nielson, VS Tayal, AE Jones, J Kellam, M Thomason, J Norton. Accuracy of ultrasound in major pelvic injury. Academic Emergency Medicine 11:580, 2004.

11) MS Runyon, WB Webb, AE Jones, JA Kline. Unstructured clinician estimate of low clinical probability for pulmonary embolism is equivalent to the Canadian score and the charlotte rule. Academic Emergency Medicine 11:448, 2004.

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